What is Citrate Lyase?

Belly FatThrough the years, there have been countless fad diets claiming to take advantage of the purported weight loss characteristics of one particular fruit or vegetable.

While most of these diets and ingredients have been scientifically proven to be at best a minor player in weight loss, or in many cases to be totally bogus.

There are occasional breakthroughs that do show potential to be effective. An example of this is the grapefruit diet, which made the claim that the chemicals found in grapefruit prompted the body to burn fat.

Though this was a simplistic explanation, it was not without merit. Now, another tropical citrus fruit named Garcinia Gummi-Gutta, commonly called Garcinia Cambogia, is growing in popularity and adding support to the efficacy of the classic grapefruit diet.

While in-depth testing is in the early stages and ongoing, the fruit shows promise, thanks in great part to the effect it has on an enzyme called ATP-citrate lyase.

Special Fat Burning Enzyme

An enzyme is a catalytic substance that acts on other molecules to help a reaction to occur or to speed up a reaction. In the case of citrate lyase, the reaction in question converts citrate and cytosolic acid (CoA) into acetyl cytosolic acid. This is the process by which lipids (fats) and cholesterol are produced.

Both of these are of course necessary in a healthy body, but in certain individuals, too much of one or both are produced and negative effects appear. A common result is weight gain.

In these cases, the citrate lyase enzyme must be regulated in order to slow down the reaction. This is where the Garcinia Cambogia fruit comes in.


A chemical found in the Garcinia Cambogia fruit, called Hydroxycitric acid, inhibits citrate lyase and slows down the process that forms ethyl cytosolic acid.

Since citrate lyase is essential to the proper metabolic functioning of a healthy body, the citrate lyase cannot simply be blocked.

Citrate lyase must be gently regulated. The Hydroxycitric acid in the Garcinia Cambogia fruit is able to do this gently and naturally.

An additional benefit of Hydroxycitric acid’s inhibiting effect on ATP citrate lyase is its potential to inhibit cell growth in tumors. Tumors are extremely hungry creatures and require large amounts of food to feed their rapidly reproducing cancerous cells.

This means that a high rate of ethyl-CoA, lipid and cholesterol production facilitated by the citrate lyase enzyme provides the cancerous cells with more food.


Just as Hydroxycitric acid aids in weight loss by acting on the citrate lyase process and inhibiting the production of lipids, it aids in starving the cancer cells by making less food available to them.

What essentially is happening is that the tumor is being starved, which at least slows growth, and may eventually kill the tumor.

There is still a lot of testing to be done, but scientists are having good results so far and have not identified any negative effects.

Like with most things, the effects that the chemical compounds found in Garcinia Cambogia, though effective, cannot work alone to achieve significant weight loss.

In order to achieve the best results from the inhibitory effects on citrate lyase, a regimen of healthy, low-carb nutrition and moderate exercise is important.

The current consensus is that when used properly, Garcinia Cambogia, with its ability to slow down the catalyst enzyme citrate lyase, is an effective tool in a weight loss and weight control strategy.


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